Research Interests:
Variability and dynamics at the interface between the cell and population levels of organization
Short Synopsis:
Phenotypic variability in cell populations. In collaboration with Erez Braun, Technion; Hanna Salman, Pittsburgh University.
H. Salman, N. Brenner, Ch-K. Tung, N. Elyahu, E. Stolovicki, L. Moore, A. Libchaber and E. Braun, “Universal protein fluctuations in microorganism populations. Phys. Rev. Lett. 108, 238105 (2012).
T. Friedlander and N. Brenner, “Cellular properties and asymptotics in the population balance equation”, Phys. Rev. Lett. 101, 018104 (2008). (pdf)
N. Brenner, K. Farkash and E. Braun, “Dynamics of protein distributions in cell populations”, Phys. Biol. 3, 172-182 (2006). (pdf)
Cooperative interactions in microorganism populations.
H. Behar, N. Brenner and Y. Louzoun, “Coexistence of productive and non-productive populations by emergence of spatio-temporal heterogeneity”. Submitted (2013).
Y. Elhanati, S. Schuster and N. Brenner, “Dynamic modeling of cooperative protein secretion in microorganism populations”. Theor. Pop. Biol. 80, 49-63 (2011).
Adaptive cellular response to signals
T. Friedlander and N. Brenner, “Adaptive response by state-dependent inactivation”. PNAS106, 22558-22563 (2009).
T. Friedlander and N. Brenner, “Adaptive response and enlargement of dynamic range”. Mathematical Biosciences and Engineering 8, 515 – 528, (2011).
G. Gilboa, R. Chen and N. Brenner, “History dependent multiple time scale dynamics in a single neuron model”, J. Neurosci. 25, 6479-6489 (2005).
Cellular adaptation to regulatory rewiring in yeast populations. In collaboration with Erez Braun, Technion.
S. Stern, T. Dror, E. Stolovicki, N. Brenner and E. Braun, “Genome-wide transcriptional plasticity underlies cellular adaptation to novel challenge”, Mol. Sys. Biol. 3, article #106 (2007) . (LINK TO: Stern_MSB2007.PDF). See also commentary by E.V. Koonin, Mol. Sys. Biol. 3, article # 107 (2007).
E. Stolovicki, T. Dror, N. Brenner and E. Braun, “Synthetic gene-recruitment reveals adaptive reprogramming of gene regulation in yeast”, Genetics 173, 75-85 (2006).