Research Interests:
Brain Systems Organization and Neurodegeneration
Short Synopsis:
Our lab uses functional magnetic resonance imaging (fMRI) combined with optogenetic tools and animal models to investigate the dynamic interaction between neural circuits. We seek to understand how these systems-level dynamics give rise to various aspects of brain function and behavior in health and disease. Whole-brain fMRI combined with single cell electrophysiology, the lab is able to study mechanisms
governing neural dynamics at the level of the microcircuit and across brain regions.
Kahn I. & Shohamy D. (2013). Intrinsic Connectivity between the Hippocampus, Nucleus Accumbens and Ventral Tegmental Area in Humans. Hippocampus 23:187-192.
Kahn I.*, Knoblich U.*, Desai M., Bernstein J., Graybiel A.M., Boyden E.S., Buckner R.L., & Moore C.I. (2013). Optogenetic Drive of Neocortical Pyramidal Neurons Generates fMRI Signals That Are Correlated with Spiking Activity. Brain Research 1511:33-45.*equal authorship
Kahn I.*, Desai M.*, Knoblich U.*, Bernstein J., Henninger M., Graybiel A. M., Boyden E.S., Buckner R.L., & Moore C.I. (2011). Characterization of the Functional MRI Response Temporal Linearity via Optical Control of Neocortical Pyramidal Neurons. Journal of Neuroscience 31:15086-15091. *equal authorship
Kahn I., Andrews-Hanna J. R., Vincent J. L., Snyder A. Z., & Buckner R. L. (2008). Distinct cortical anatomy linked to subregions of the medial temporal lobe revealed by intrinsic functional connectivity. Journal of Neurophysiology 100(1):129-139.
Kahn I., Davachi L., & Wagner A. D. (2004). Functional-neuroanatomic correlates of recollection: Implications for models of recognition memory. Journal of Neuroscience 24:4172-4180.